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Using Gpx4 deletion models, genetic fate-mapping, and single-cell transcriptomics, we found that proximal tubule cells that escape acute ferroptotic death adopt a new proinflammatory state, which we termed inflammatory proximal tubule cells (iPTCs) (Figure 2)

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“Vitamin C, for example, is involved in collagen synthesis and can help address uneven pigmentation, so you’re getting both preventive and corrective benefits,” says Dr