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35 The endothelium regulates the adhesion and infiltration of immune cells and controls vascular tone by releasing a balance of vasoconstrictive (e.g., endothelin-1) and vasodilatory (e.g., nitric oxide (NO)) factors

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23, 24, 25 In three independent case/control cohorts, children with autism were shown to exhibit abnormal plasma levels of metabolites in the pathway of glutathione redox metabolism