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In ovalbumin (OVA) and house dust mite-induced asthma models, pulmonary Acod1/Irg1 expression and itaconate levels are markedly upregulated, whereas Acod1-deficient mice exhibit exacerbated type II inflammation, including elevated IL-5/IL-13, increased serum IgE, enhanced eosinophil infiltration, and worsened airway hyperreactivity
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